INTERACTION CHECKER.

Cannabis may increase or decrease SSRI blood levels. Some reports suggest cannabis may increase anxiety when combined with SSRIs. Monitor for changes in mood, anxiety, and side effects. Do not stop SSRIs suddenly.

SOURCE: NIDA Cannabis Research Report; pharmacology literature

Similar to SSRIs. Cannabis may affect SNRI metabolism. Monitor for changes in mood, anxiety, blood pressure, and side effects. Do not stop SNRIs suddenly — withdrawal can occur.

SOURCE: NIDA Cannabis Research Report; pharmacology literature

Both cannabis and benzodiazepines are central nervous system depressants. Combining them increases sedation, dizziness, cognitive impairment, and risk of accidents. Do not combine without medical supervision. Do not stop benzodiazepines suddenly — withdrawal can be dangerous.

SOURCE: FDA drug safety communications; pharmacology literature

Combining cannabis with sleep medications increases sedation, dizziness, and morning grogginess. Increased risk of falls, especially in older adults. Discuss with your provider before combining.

SOURCE: FDA drug safety communications; CDC cannabis information

Combining cannabis with opioids increases sedation and may increase respiratory depression risk. The interaction is not fully understood. Do not combine without medical supervision. Do not stop or reduce opioids suddenly — withdrawal can be severe.

SOURCE: CDC opioid prescribing guidelines; pharmacology literature

Cannabis may affect anticonvulsant metabolism and seizure threshold. Monitor for changes in seizure frequency, dizziness, and sedation. Discuss with your neurologist before combining.

SOURCE: Epilepsy Foundation; pharmacology literature

Cannabis may affect warfarin metabolism and increase bleeding risk. Close monitoring of INR is essential. Do not start or stop cannabis without discussing with your provider if you take warfarin.

SOURCE: FDA drug safety communications; pharmacology literature

Cannabis can affect heart rate and blood pressure. Combining with blood pressure medications may cause dizziness, lightheadedness, or fainting — especially when standing up. Monitor blood pressure regularly.

SOURCE: AHA cannabis guidance; pharmacology literature

Cannabis may interact with older antidepressants. MAOIs have serious interaction potential with many substances. Discuss with your psychiatrist before combining.

SOURCE: Pharmacology literature; FDA drug safety communications

Combining cannabis with alcohol increases impairment, dizziness, and risk of accidents. Alcohol can increase THC absorption. The combination can cause nausea and vomiting in some individuals.

SOURCE: CDC cannabis information; NIDA Cannabis Research Report